Neurobiology of Disease Ca -Permeable AMPA Receptors Regulate Growth of Human Glioblastoma via Akt Activation
نویسندگان
چکیده
Shogo Ishiuchi,1 Yukari Yoshida,2 Kenichi Sugawara,1 Masanori Aihara,1 Toshiyuki Ohtani,1 Takashi Watanabe,1 Nobuhito Saito,1 Keisuke Tsuzuki,2 Haruo Okado,4 Akiko Miwa,4 Yoichi Nakazato,3 and Seiji Ozawa2 Departments of 1Neurosurgery, 2Neurophysiology, and 3Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, and 4Department of Molecular Physiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu 183-8526, Japan
منابع مشابه
Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes.
Oligodendrocytes are vulnerable to excitotoxic insults mediated by AMPA receptors and by low and high affinity kainate receptors, a feature that is dependent on Ca(2+) influx. In the current study, we have analyzed the intracellular concentration of calcium [Ca(2+)](i) as well as the entry routes of this cation, upon activation of these receptors. Selective activation of either receptor type re...
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